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AbPlus GPCR HTS Assay System

AbPlus GPCR HTS Assay System is a newly developed live cell-based assay platform for functional screening of Gi-coupled GPCR antibodies. This proprietary TRPC biosensor has been modulated specifically to detect Gi-coupled GPCR activity through a direct Gαi-TRPC interaction.

Advantages:

• Cell-based assay presents the epitope in its native conformation state

• More physiologically relevant assay conditions

• Highly sensitive, robust signal, and adaptable to various high throughput screen formats

• Well suited not only for screening for agonists/antagonists, but also for screening for allosteric regulators, partial agonists/antagonists

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