Influenza Virus Research

Influenza viruses belong to the family Orthomyxoviridae. The viral particles are about 80-120 nm in diameter and can be spherical or pleomorphic. They have a lipid membrane envelope that contains the two glycoproteins: hemagglutinin (HA) and neuraminidase (NA). These two proteins determine the subtypes of Influenza A virus. There are 16 H subtypes and 9 N subtypes.

The surface glycoprotein hemagglutinin (HA) is the major surface antigen of influenza viruses, against which neutralizing antibodies are elicited during virus infection and vaccination. HA is synthesized as a single polypeptide that is subsequently cleaved into two polypeptides, HA1 and HA2. The HA1 polypeptide mutates more frequently than HA2 and plays a crucial role in natural selection.

The Influenza A viral genome consists of eight, single negative-strand RNAs that can range between 890 and 2340 nucleotides long. Each RNA segment encodes one to two proteins. Of the three types of influenza virus-A, B and C-the A and B types can cause flu epidemics.

 

Influenza Virus Research Products (recombinant proteins, antibodies, ORF cDNA clones, etc)

Influenza A Virus

● H1N1	● H2N2	● H3N2	● H4N6	● H5N1	● H5N2
● H5N3	● H5N8	● H6N1	● H6N2	● H7N2	● H7N7
● H8N4	● H9N2	● H11N2	● H12N5	● H13N8	● H15N8
● H16N3

                                                                                                                                                                        

Influenza B Virus

● B/Brisbane/60/2008

● B/Florida/4/2006

● B/Malaysia/2506/2004

● B/Tokyo/53/99