Synonym: Angiotensin Converting Enzyme 2, ACEH, Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2, Angiotensin-Converting Enzyme-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, Angiotensin I Converting Enzyme 2, Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Metalloprotease MPROT15, Peptidyl-Dipeptidase A, EC 3.4.17.23, EC 3.4.17

About Human Angiotensin-Converting Enzyme 2 (ACE2) Stable Cell Line

Human Angiotensin-Converting Enzyme 2 (ACE2) is a type I transmembrane protein that serves as a critical regulator of the renin-angiotensin system (RAS) and plays essential roles in cardiovascular physiology, blood pressure regulation, inflammation, and tissue homeostasis. ACE2 functions as a zinc-dependent carboxypeptidase that converts angiotensin II into angiotensin-(1-7), thereby counterbalancing the vasoconstrictive, pro-inflammatory, and pro-fibrotic effects of angiotensin II. ACE2 is widely expressed in multiple tissues including the lung, heart, kidney, intestine, and vascular endothelium, where it contributes to maintaining normal physiological function and tissue protection.

ACE2 has gained global attention as the primary cellular receptor utilized by SARS-CoV, SARS-CoV-2, and related coronaviruses for host-cell entry. The receptor-binding domain (RBD) of the coronavirus spike protein specifically recognizes and binds ACE2, initiating viral attachment and infection. Because of its central role in coronavirus biology and its physiological importance in the renin-angiotensin system, ACE2 has become a key target for studies of viral pathogenesis, receptor biology, therapeutic antibody development, antiviral drug discovery, and cardiovascular research.

eEnzyme's Human ACE2 Stable Cell Line provides a reliable and reproducible cellular platform for investigating ACE2-mediated biological processes and receptor-ligand interactions. The cell line enables functional evaluation of coronavirus spike proteins, receptor-binding studies, neutralizing antibodies, soluble receptor therapeutics, and small-molecule inhibitors. Researchers can utilize this stable cell line to characterize ACE2 interactions, investigate viral entry mechanisms, evaluate compound potency, and support drug discovery programs targeting infectious diseases and ACE2-associated signaling pathways.

Applications of the ACE2 Stable Cell Line

• SARS-CoV-2 spike protein binding studies
• Coronavirus entry and infection research
• Neutralizing antibody screening and characterization
• Antiviral drug discovery and development
• ACE2 receptor biology investigations
• Receptor-ligand interaction assays
• Cardiovascular and renin-angiotensin system research
• High-throughput screening applications

Biological Significance of ACE2

ACE2 serves dual roles as both an essential physiological regulator and a viral entry receptor. Within the renin-angiotensin system, ACE2 promotes protective cardiovascular, pulmonary, and renal effects through conversion of angiotensin II into angiotensin-(1-7). In infectious disease biology, ACE2 functions as the primary receptor for SARS-CoV and SARS-CoV-2, mediating viral attachment and entry into host cells. The interaction between ACE2 and coronavirus spike proteins represents the critical first step in infection and has become a major focus of antiviral therapeutic development. Because of its importance in cardiovascular homeostasis, inflammation, tissue protection, and viral pathogenesis, ACE2 remains one of the most extensively studied proteins in infectious disease research, cardiovascular biology, and translational medicine. The ACE2 Stable Cell Line provides a valuable tool for investigating receptor function, virus-host interactions, and therapeutic strategies targeting ACE2-mediated pathways.