1) ACTOne GPCR assay is a live cell-based cAMP biosensor detection system generated for high-throughput functional screening of G-protein coupled receptors.
• Over 60 GPCR stable cell lines established and being developed
• Highly sensitive and big assay windows
• Excellent signal-to-noise ratio and reproducibility
• Real time kinetic assay or end point assay
• Work for both endogenous or recombinant GPCRs
• Agonist and antagonist screening in one assay
Click below for a 22-page-ppt overview of the technology:
2) AbPlus GPCR HTS Assay System is a newly developed live cell-based assay platform for functional screening of Gi-coupled GPCR antibodies. This proprietary TRPC biosensor has been modulated specifically to detect Gi-coupled GPCR activity through a direct Gαi-TRPC interaction.
Advantages:
• Cell-based assay presents the epitope in its native conformation state
• More physiologically relevant assay conditions
• Highly sensitive, robust signal, and adaptable to various high throughput screen formats
• Well suited not only for screening for agonists/antagonists, but also for screening for allosteric regulators, partial agonists/antagonists