CL-11-CXCR4

Name

Chemokine (C-X-C Motif) Receptor 4 (CXCR4) ACTOne^TM Stable Cell Line

Description

This cell line is a HEK-293-CNG cell line that expresses a recombinant human CXCR4. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.

Application

cAMP dependent human CXCR4 cell-based assay;

cell-based high-throughput screening of human CXCR4 agonists/antagonists.

Size

1x 10⁶ cells

Detection

FlexStation or Microplate reader

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