EBV (HHV-4) gH/gL/gp42 Protein Complex
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Catalog Number:
HHV4-gHL42-23P
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Old name: HHV4-gHL42-05p
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Detailed Description
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HHV4-gHL42-23P
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Name
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Epstein–Barr virus gH/gL/gp42 protein complex
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Description
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C-terminal 6xHis-tagged recombinant EBV (or HHV-4) gH (aa 19-678)(GenBank accession#: P03231) in complex with gL (aa 23-137)(GenBank accession#: CAD53428) and gp42 (aa 31-223)(Genbank accession#: YP_401672)
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Source
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Expressed and purified from HEK293 cells
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Application
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Western Blot, ELISA, etc.
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Purity
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>95% (by 10% SDS-PAGE gel)
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Size
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50 µg
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For Downloading
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==>> Data Sheet ==>> Safety Data Sheet
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About the EBV gH/gL/gp42 Protein Complex
The Epstein-Barr virus (EBV, Human Herpesvirus 4) gH/gL/gp42 complex is a critical component of the viral entry machinery required for infection of B lymphocytes. The complex consists of glycoprotein H (gH), glycoprotein L (gL), and gp42, which function together to mediate receptor recognition and membrane fusion during viral entry. Binding of gp42 to HLA class II molecules on B cells triggers conformational changes that activate the EBV fusion machinery and facilitate viral infection. The gH/gL/gp42 complex therefore plays a central role in determining EBV host-cell tropism and infectivity.
Because of its essential role in viral entry, the gH/gL/gp42 complex has become an important target for EBV vaccine development, neutralizing antibody discovery, structural biology studies, and antiviral therapeutic research. Multiple studies have demonstrated that antibodies targeting gH, gL, or gp42 can block EBV infection and provide valuable insights into mechanisms of viral neutralization.
eEnzyme's recombinant EBV gH/gL/gp42 protein complex is expressed in HEK293 cells and is suitable for ELISA, Western blotting, antibody screening, vaccine research, receptor-binding studies, and structural characterization. The protein complex can be used to support investigations of EBV entry mechanisms, host-cell tropism, neutralizing antibody development, and next-generation vaccine design.
Applications of the EBV gH/gL/gp42 Protein Complex
• Neutralizing antibody discovery and characterization
• EBV vaccine development research
• Viral entry and membrane fusion studies
• Receptor-binding and HLA interaction studies
• Structural biology and epitope mapping
• ELISA, Western blot, and immunological assays
Biological Significance of the gH/gL/gp42 Complex
The gH/gL/gp42 complex functions as a key trigger for EBV entry into B cells. gp42 binds host HLA class II receptors, while gH/gL coordinates activation of the viral fusion protein gB, ultimately promoting membrane fusion and viral infection. Because this complex is essential for B-cell infection and EBV pathogenesis, it remains a major focus of vaccine, antibody, and antiviral research programs.
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