Glucagon-Like Peptide 2 Receptor (GLP2R) ACTOne Stable Cell Line
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Catalog Number:
CL-01-GLP2R
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In Stock
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Price: Please inquire order@eEnzyme.com
Detailed Description
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CL-01-GLP2R
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Name
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Glucagon-Like Peptide 2 Receptor (GLP2R) ACTOneTM Stable Cell Line
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Description
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This cell line is a HEK-293 CNG cell line that expresses a recombinant human GLP2R. HEK-293 CNG-Slcla3 cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.
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Application
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cAMP dependent human GLP2R cell-based assay;
cell-based high-throughput screening of human GLP2R agonists/antagonists.
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Size
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1x 106 cells
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Detection
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FlexStation or Microplate reader
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For Downloading
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==>> DATA SHEET ==>> MSDS
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Synonym: Glucagon Like Peptide 2 Receptor, GLP-2 Receptor, Epididymis Secretory Sperm Binding Protein, GLP-2-R, GLP-2R
About Human Glucagon-Like Peptide-2 Receptor (GLP2R) Stable Cell Line
Glucagon-Like Peptide-2 Receptor (GLP2R), also known as GLP-2 receptor, is a Class B G protein-coupled receptor (GPCR) that is activated by the intestinal hormone glucagon-like peptide-2 (GLP-2). GLP2R primarily couples to Gs proteins, stimulating adenylate cyclase activity and increasing intracellular cAMP levels to regulate signaling pathways involved in intestinal growth, nutrient absorption, epithelial repair, and gastrointestinal function. The receptor is predominantly expressed in the gastrointestinal tract, particularly in intestinal subepithelial myofibroblasts, enteric neurons, and enteroendocrine cells.
GLP2R plays a critical role in maintaining intestinal mucosal integrity by promoting crypt cell proliferation, increasing villus height, reducing enterocyte apoptosis, and enhancing intestinal barrier function. Because of these physiological functions, GLP2R has become an important therapeutic target for short bowel syndrome, inflammatory bowel disease (IBD), intestinal failure, and other gastrointestinal disorders.
eEnzyme's Human GLP2R Stable Cell Line provides a reliable platform for investigating GLP2R-mediated signaling and evaluating GLP-2 analogs, agonists, antagonists, and novel receptor modulators using cAMP and other GPCR functional assays. The cell line is well suited for receptor characterization, compound profiling, potency determination, and high-throughput drug screening.
Applications
• GLP2R receptor pharmacology studies
• GLP-2 signaling research
• Agonist and antagonist screening
• Gastrointestinal drug discovery
• Short bowel syndrome research
• Intestinal regeneration and barrier function studies
• cAMP and GPCR functional assays
• High-throughput screening (HTS)
Biological Significance of GLP2R
GLP2R is a key regulator of intestinal growth, epithelial repair, and gastrointestinal homeostasis. Activation of the receptor stimulates cAMP-dependent signaling pathways that promote intestinal epithelial proliferation, suppress apoptosis, improve nutrient absorption, increase intestinal blood flow, and strengthen mucosal barrier function. These protective effects have established GLP2R as an important therapeutic target for intestinal failure, short bowel syndrome, inflammatory bowel disease, and other gastrointestinal disorders. In addition, GLP2R signaling continues to be investigated for its potential roles in metabolic regulation and gut health. The GLP2R Stable Cell Line provides a valuable tool for studying GLP-2 receptor biology and accelerating the development of next-generation therapeutics for gastrointestinal diseases.
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