About Herpes Simplex Virus Type 2 (HSV-2) Glycoprotein D (gD) Recombinant Protein

Herpes Simplex Virus Type 2 (HSV-2) is an enveloped double-stranded DNA virus belonging to the genus Simplexvirus in the family Herpesviridae. Glycoprotein D (gD) is an essential viral envelope glycoprotein that mediates viral attachment and entry by binding cellular receptors, including HVEM (TNFRSF14) and nectin-1 (PVRL1). Binding of gD activates the viral fusion machinery composed of gB and the gH/gL complex, enabling membrane fusion and viral entry. Because of its critical role in infection and its strong immunogenicity, gD is the primary target of neutralizing antibodies and an important antigen for HSV vaccine development, therapeutic antibody discovery, and antiviral research.

eEnzyme's HSV-2 Glycoprotein D (gD) Recombinant Protein is produced for research use and is suitable for antibody screening, receptor-binding studies, ELISA development, Western blotting, epitope mapping, structural characterization, and HSV vaccine research. This recombinant protein provides a valuable reagent for investigating HSV-2 entry mechanisms, host-virus interactions, immune responses, and the development of antiviral therapeutics.

Applications

Biological Significance of HSV-2 Glycoprotein D

HSV-2 gD is the key receptor-binding protein that initiates viral infection by engaging host cell receptors and triggering membrane fusion. As the major target of virus-neutralizing antibodies, gD has become one of the most extensively studied HSV antigens for vaccine development, therapeutic antibody discovery, and antiviral drug research. The HSV-2 Glycoprotein D Recombinant Protein provides a valuable research tool for studies of herpesvirus biology, immune responses, receptor interactions, and the development of next-generation vaccines and therapeutics.