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5-Hydroxytryptamine (Serotonin) Receptor 4 (HTR4) ACTOne Stable Cell Line

Catalog Number:
CL-01-HTR4
This price is only valid for academic research use; please quote if for industrial use. Restrictions apply. Please inquire.
Price: $4,999.00
Detailed Description

 

CL-01-HTR4

Name

5-Hydroxytryptamine (Serotonin) Receptor 4 (HTR4) ACTOneTM Stable Cell Line

Description

This cell line is a HEK-293-CNG cell line that expresses a recombinant human HTR4. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.

Application

cAMP dependent human HTR4 cell-based assay;

cell-based high-throughput screening (HTS) of human HTR4 agonists/antagonists

Size

1x 106 cells

Detection

FlexStation or Microplate reader

 

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