CL-01-HTR7B

Name

5-Hydroxytryptamine (Serotonin) Receptor 7B (HTR7B) ACTOne^TM Stable Cell Line

Description

This cell line is a HEK-293-CNG cell line that expresses a recombinant human HTR7B. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.

Application

cAMP dependent human HTR7B cell-based assay;

cell-based high-throughput screening of human HTR7B agonists/antagonists.

Size

1 mL (frozen cells, 1x 10⁶ cells before freezing)

Detection

FlexStation or Microplate reader

For Downloading

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