About Human CD4 Recombinant Protein

CD4 is a type I transmembrane glycoprotein primarily expressed on helper T lymphocytes (CD4⁺ T cells), as well as on monocytes, macrophages, and dendritic cells. CD4 functions as a co-receptor for the T-cell receptor (TCR) by binding major histocompatibility complex class II (MHC II) molecules on antigen-presenting cells, thereby enhancing T-cell activation and adaptive immune responses. CD4 also serves as the primary cellular receptor for the HIV-1 envelope glycoprotein gp120, making it a key molecule in HIV entry and pathogenesis.

eEnzyme's Human CD4 Recombinant Protein is produced for research use and is suitable for receptor-ligand interaction studies, HIV gp120 binding assays, antibody generation, ELISA development, Western blotting, protein-protein interaction studies, and immunological research. This recombinant protein provides a valuable reagent for investigating T-cell biology, immune regulation, HIV entry mechanisms, and therapeutic antibody development.

Applications

Applications

Biological Significance of Human CD4

CD4 is a critical immune co-receptor that enhances antigen recognition by stabilizing interactions between the T-cell receptor and MHC class II molecules while recruiting the Src family kinase Lck to initiate intracellular signaling. In addition to its essential role in adaptive immunity, CD4 is the primary receptor exploited by HIV-1 to infect susceptible cells. Consequently, Human CD4 Recombinant Protein is widely used for studies of T-cell signaling, immune regulation, HIV-host interactions, therapeutic antibody discovery, and antiviral drug development.