Melanocortin 4 Receptor (MC4R) ACTOne Stable Cell Line
|
Catalog Number:
CL-01-MC4R
|
Price: Please inquire order@eEnzyme.com
Detailed Description
|
CL-01-MC4R
|
|
Name
|
Melanocortin 4 Receptor (MC4R) ACTOneTM Stable Cell Line
|
|
Description
|
This cell line is a HEK-293-CNG cell line that expresses a recombinant human MC4R. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.<
|
|
Application
|
cAMP dependent human MC4R cell-based assay;
cell-based high-throughput screening of human MC4R agonists/antagonists.
|
|
Size
|
1x 106 cells
|
|
Detection
|
FlexStation or Microplate reader
|
|
For Downloading
|
==>> DATA SHEET ==>> MSDS
|
Selected Citation:
Hammad,et al. MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort. Front. Endocrinol., 07 July 2020
Synonym: Melanocortin 4 Receptor, Melanocortin Receptor 4, MC4-R, Mutant Melanocortin-4 Receptor, BMIQ20
|
|
|