Melanocortin 4 Receptor (MC4R) ACTOne Stable Cell Line

Catalog Number:
CL-01-MC4R
Price: Please inquire order@eEnzyme.com
Detailed Description

CL-01-MC4R

Name

Melanocortin 4 Receptor (MC4R)  ACTOneTM Stable Cell Line

Description

This cell line is a HEK-293-CNG cell line that expresses a recombinant human MC4R. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.<

Application

cAMP dependent human MC4R cell-based assay;

cell-based high-throughput screening of human MC4R agonists/antagonists.

Size

1x 106 cells

Detection

FlexStation or Microplate reader

For Downloading

==>> DATA SHEET        ==>> MSDS

 

Selected Citation:
Hammad,et al. MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort. Front. Endocrinol., 07 July 2020

Synonym: Melanocortin 4 Receptor, Melanocortin Receptor 4, MC4-R, Mutant Melanocortin-4 Receptor, BMIQ20



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