About Phlebovirus Glycoprotein G1 (Gn)

Phleboviruses are enveloped RNA viruses belonging to the family Phenuiviridae and include important human and veterinary pathogens such as Rift Valley fever virus (RVFV), Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), and Heartland virus. Viral infection is initiated through the coordinated action of two envelope glycoproteins, G1 (Gn) and G2 (Gc), which mediate host-cell attachment, viral entry, membrane fusion, and virion assembly.

Glycoprotein G1 (Gn) is a major structural component of the viral envelope and plays an essential role in receptor interaction, virion organization, and protection of the fusion machinery during viral entry. Gn forms a heterodimeric complex with Gc and contributes to the highly ordered glycoprotein lattice present on the virion surface. Because Gn is exposed on the viral envelope and participates in host-cell interactions, it represents an important target for vaccine development, neutralizing antibody discovery, and antiviral research.

eEnzyme's recombinant Phlebovirus Glycoprotein G1 (Gn) is expressed in mammalian cells and is suitable for antibody generation, vaccine research, receptor-binding studies, structural biology investigations, and immunological assay development. The protein can be utilized to support studies of viral entry mechanisms, host-pathogen interactions, epitope mapping, and immune response characterization.

Applications of Phlebovirus Glycoprotein G1

• Vaccine development and antigen evaluation
• Neutralizing antibody discovery and characterization
• Viral attachment and entry studies
• Receptor-binding investigations
• Structural biology and epitope mapping
• ELISA, Western blot, and immunological assays

Biological Significance of Glycoprotein G1

Phlebovirus Glycoprotein G1 functions together with Glycoprotein G2 to mediate the earliest stages of viral infection. Gn contributes to host-cell attachment and helps organize the viral surface architecture required for efficient entry. In several phleboviruses, Gn has been identified as a major target of protective immune responses and neutralizing antibodies, making it an attractive antigen for vaccine and therapeutic development. Structural studies have demonstrated that Gn also plays an important role in protecting and regulating the fusion activity of Gc during the viral entry process.