Sphingosine-1-phosphate Receptor 1 (S1PR1) ACTOne Stable Cell Line

Catalog Number:
CL-11-S1PR1
Price: Please inquire order@eEnzyme.com
Detailed Description

CL-11-S1PR1

Name

Sphingosine-1-phosphate Receptor 1 (S1PR1) ACTOneTM Stable Cell Line

Description

This cell line is a HEK-293-CNG cell line that expresses a recombinant human S1PR1. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.

Application

cAMP dependent assay for Gi-coupled human S1PR1;

cell-based high-throughput screening of human S1PR1 inhibitors.

Size

1x 106 cells

Detection

FlexStation or Microplate reader

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==>> DATA SHEET      ==>> MSDS





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