SARS-CoV-2 Pseudoviral Particles, Omicron BA.2 Variant
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Catalog Number:
SCV2-PsV-OmiBA2
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SARS-CoV-2 Pseudoviral Particles, replication-deficient MLV pseudotyped with the SARS-CoV-2 spike protein (the Omicron BA.2 variant). (Mobile users please click "View Full Site" for details)
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Detailed Description
Keyword: coronavirus, SARS, SARS-Cov, SARS-COV-2, covid19, covid-19, SARS pseudovirus, sars-cov-2 pseudovirus, sars-cov-2 spike, MLV, ace2, Omicron, Omicron variant
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SCV2-PsV-OmiBA2
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Name
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SARS-CoV-2 Pseudoviral Particles, Omicron BA.2 Sub-Variant (B.1.1.529+BA*)
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Description
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The SARS-CoV-2 Pseudoviral Particles are replication-deficient Maloneymurine leukemia virus (MLV or MuLV) pseudotyped with the SARS-CoV-2 spike protein carrying the Omircon BA.2 sub-variant genotype.
MLV-based virus system is a better choice than HIV-based lentivirus system for making pseudoviral particles in regards of lab safety and product quality. Gag-Pol is the only component from MLV.
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Applications
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Our Pseudovirus Particles generate robust chemiluminescent signals in cell assays when coupled with our firefly luciferase assay kit (Catalog # CA-L165), useful for 1) screening potential inhibitors to block SARS-CoV-2 entry and viral protein; 2) measuring the activity of and screening for neutralizing antibody against SARS-CoV-2.
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Size
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5 ml, for one multi-well plate; Pseudoviral particles per mL > 1.0E+07
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Storage
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-70oC. Shipped on dry ice.
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Note
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1. Amenable to HTS format (96-well, 384-well and 1536-well format).
2. HEK293-hACE2 stable cells are available seperately (Cat..# CL-hACE2-001, CL-hACE2-002)
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For Downloading
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==>> DATA SHEET ==>> SAFETY DATA SHEET
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Background Knowledge
WHO Statement
Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
26 Nov. 2021
1. "The B.1.1.529 variant was first reported to WHO from South Africa on 24 November 2021. "
2. "The first known confirmed B.1.1.529 infection was from a specimen collected on 9 November 2021."
3. "Current SARS-CoV-2 PCR diagnostics continue to detect this variant."
The "S gene dropout" or "S gene target failure" marker makes it easy to detect the Omicron variant among the positive cases.
4. Omicron includes the lineages BA.1, BA.2, BA.3 and B.1.1.529. BA.1 accounts for most of the cases. BA.2 was first detected in the Philippines. While BA.1 and BA.2 are similar, they are 20 mutations apart.
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