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SARS-CoV-2 Pseudoviral Particles, Beta Variant (South Africa B.1.351)

Catalog Number:
SCV2-PsV-SA
SARS-CoV-2 Pseudoviral Particles, replication-deficient MLV pseudotyped with the SARS-CoV-2 spike protein (the South Africa variant). (Mobile users please click "View Full Site" for details)
Price: $900.00
Detailed Description
Keyword: coronavirus, SARS, SARS-Cov, SARS-COV-2, covid19, covid-19, SARS pseudovirus, sars-cov-2 pseudovirus, sars-cov-2 spike, MLV, ace2, B.1.351, covid South Africa variant

SCV2-PsV-SA

Name

SARS-CoV-2 Pseudoviral Particles, Beta Variant (South Africa B.1.351) 

Description

The SARS-CoV-2 Pseudoviral Particles are replication-deficient Maloneymurine leukemia virus (MLV or MuLV) pseudotyped with the SARS-CoV-2 spike protein of the Beta Variant (South Africa B.1.351, a.k.a. 20H/501Y.V2, formerly 20C/501Y.V2) (GISAID sequence accession number: EPI_ISL_736980). 
MLV-based virus system is a better choice than HIV-based lentivirus system for making pseudoviral particles in regards of lab safety and product quality. Gag-Pol is the only component from MLV.

Applications

Our Pseudovirus Particles generate robust chemiluminescent signals in cell assays when coupled with our firefly luciferase assay kit (Catalog # CA-L165), useful for 1) screening potential inhibitors to block SARS-CoV-2 entry and viral protein; 2) measuring the activity of and screening for neutralizing antibody against SARS-CoV-2. 

Size

10 ml (2 tubes, 5 mL/tube), for 2 multi-well plates. Pseudoviral particles per mL ~ 1.0E+08

Storage

 -70 C. Shipped on dry ice.

Note

1. Amenable to HTS format (96-well, 384-well and 1536-well format). Biosafety Level 2.
2. HEK293-hACE2 stable cell lines are available seperately (Cat.# CL-hACE2-001, CL-hACE2-002)


==>> DATA SHEET

==>> GHS SDS

Reference:  Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa. 
https://www.medrxiv.org/content/10.1101/2020.12.21.20248640v1.full

 

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