SARS-CoV-2 Pseudoviral Particles, Alpha Variant (UK B.1.1.7)
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Catalog Number:
SCV2-PsV-UK
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SARS-CoV-2 Pseudoviral Particles, replication-deficient MLV pseudotyped with the SARS-CoV-2 spike protein (the UK variant B.1.1.7 "Alpha"). (Mobile users please click "View Full Site" for details)
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Detailed Description
Keyword: coronavirus, SARS, SARS-Cov, SARS-COV-2, covid19, covid-19, SARS pseudovirus, sars-cov-2 pseudovirus, sars-cov-2 spike, MLV, ace2, covid south africa variant, B.1.351
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SCV2-PsV-UK
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Name
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SARS-CoV-2 Pseudoviral Particles, Alpha Variant (UK B.1.1.7)
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Description
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The SARS-CoV-2 Pseudoviral Particles are replication-deficient Maloneymurine leukemia virus (MLV or MuLV) pseudotyped with the SARS-CoV-2 spike protein of the Alpha variant (UK B.1.1.7, a.k.a. 201/501Y.V1, VOC 202012/01) (GISAID sequence accession number: EPI_ISL_601443).
MLV-based virus system is a better choice than HIV-based lentivirus system for making pseudoviral particles in regards of lab safety and product quality. Gag-Pol is the only component from MLV.
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Applications
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Our Pseudovirus Particles generate robust chemiluminescent signals in cell assays when coupled with our firefly luciferase assay kit (Catalog # CA-L165), useful for 1) screening potential inhibitors to block SARS-CoV-2 entry and viral protein; 2) measuring the activity of and screening for neutralizing antibody against SARS-CoV-2.
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Size
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5 ml, for one multi-well plate. Pseudoviral particles per mL ~ 1.0E+08
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Storage
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-70oC. Shipped on dry ice.
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Note
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1. Amenable to HTS format (96-well, 384-well and 1536-well format).
2. HEK293-hACE2 stable cell lines are available seperately (Cat.# CL-hACE2-001, CL-hACE2-002)
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For Downloading
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==>> DATA SHEET ==>> SAFETY DATA SHEET
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This product has been used in a lot COVID research work. Here are a citation for reference:
Development and Characterization of Phage-Display-Derived Novel Human Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2. Biomedicines 2022, 10(12), 3274
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