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SARS-CoV-2 Pseudoviral Particles, D614G-N501Y

Catalog Number:
SCV2-PsV-501Y
SARS-CoV-2 Pseudoviral Particles, replication-deficient MLV pseudotyped with the SARS-CoV-2 spike protein (the 614G-501Y variant). (Mobile users please click "View Full Site" for details)
Price: $900.00
Detailed Description
Keyword: coronavirus, SARS, SARS-Cov, SARS-COV-2, covid19, covid-19, SARS pseudovirus, sars-cov-2 pseudovirus, sars-cov-2 spike, MLV, ace2, D614G, 614G, A222V, 222V

SCV2-PsV-501Y

Name

SARS-CoV-2 Pseudoviral Particles, D614G-N501Y

Description

The SARS-CoV-2 Pseudoviral Particles are replication-deficient Maloneymurine Leukemia Virus (MLV or MuLV) pseudotyped with the SARS-CoV-2 spike protein of the 20E (EU1) variant carrying (Genbank Accession # QHD43416.1, p.501N-->Y, p.614D-->G).
MLV-based virus system is a better choice than HIV-based lentivirus system for making pseudoviral particles in regards of lab safety and product quality. Gag-Pol is the only component from MLV.

Applications

Our Pseudovirus Particles generate robust chemiluminescent signals in cell assays when coupled with our firefly luciferase assay kit (Catalog # CA-L165), useful for 1) screening potential inhibitors to block SARS-CoV-2 entry and viral protein; 2) measuring the activity of and screening for neutralizing antibody against SARS-CoV-2.

Size

10 ml (2 tubes, 5 mL/tube), for 2 multi-well plates. Pseudoviral particles per mL ~ 1.0E+08

Storage

 -70 C. Shipped on dry ice.

Note

1. Amenable to HTS format (96-well, 384-well and 1536-well format). Biosafety Level 2.
2. HEK293-hACE2 stable cells are available seperately (Cat.# CL-hACE2-001, CL-hACE2-002)


==>> DATA SHEET

==>> SAFETY DATA SHEET

Reference: The N501Y spike substitution enhances SARS-CoV-2 transmission 

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