Somatostatin Receptor 5 (SSTR5) ACTOne Stable Cell Line
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Catalog Number:
CL-11-SSTR5
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In Stock
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Price: Please inquire order@eEnzyme.com
Detailed Description
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CL-11-SSTR5
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Name
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Somatostatin Receptor 5 (SSTR5) ACTOneTM Stable Cell Line |
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Description
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This cell line is a HEK-293-CNG cell line that expresses a recombinant human SSTR5. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.
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Application
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cAMP dependent assay for Gi-coupled human SSTR5;
Cell-based high-throughput screening of human SSTR5 agonists/antagonists.
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Size
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1x 106 cells/p>
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Detection
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FlexStation or Microplate reader
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For Downloading
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==>> DATA SHEET ==>> MSDS
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Synonym: Somatostatin Receptor 5, Somatostatin Receptor Type 5, SS-5-R, SST5, Somatostatin Receptor Subtype 5, SS5-R, SS5R
About Human Somatostatin Receptor 5 (SSTR5/SST5) Stable Cell Line
Somatostatin Receptor 5 (SSTR5), also known as SST5, is a Class A G protein-coupled receptor (GPCR) that binds the endogenous peptide hormones somatostatin-14 (SST-14) and somatostatin-28 (SST-28). SSTR5 primarily couples to Gi/o proteins, resulting in inhibition of adenylate cyclase activity, reduced intracellular cAMP production, and modulation of hormone secretion and cell proliferation. The receptor is highly expressed in the pituitary gland, pancreas, gastrointestinal tract, and selected regions of the central nervous system, where it regulates endocrine and neuroendocrine functions.
SSTR5 plays important roles in regulating the secretion of growth hormone (GH), insulin, glucagon, prolactin, and adrenocorticotropic hormone (ACTH). The receptor has become an important therapeutic target for acromegaly, Cushing's disease, neuroendocrine tumors, diabetes, and other endocrine disorders. Clinically, somatostatin analogs such as pasireotide exhibit high affinity for SSTR5, further highlighting its therapeutic significance.
eEnzyme's Human SSTR5 Stable Cell Line provides a reliable platform for investigating SSTR5-mediated signaling and evaluating agonists, antagonists, and novel receptor modulators using cAMP and other GPCR functional assays. The cell line is well suited for receptor characterization, compound profiling, potency determination, and high-throughput drug screening.
Applications
• SSTR5 receptor pharmacology studies
• Somatostatin signaling research
• Agonist and antagonist screening
• Acromegaly and Cushing's disease research
• Neuroendocrine tumor drug discovery
• Endocrine and metabolic disease studies
• cAMP and GPCR functional assays
• High-throughput screening (HTS)
Biological Significance of SSTR5
SSTR5 is a key regulator of endocrine hormone secretion and cellular growth. Activation of the receptor suppresses the release of multiple peptide hormones, including growth hormone, insulin, glucagon, and ACTH, through Gi/o-mediated signaling pathways. Because of its central role in endocrine regulation, SSTR5 has become an important target for the treatment of pituitary adenomas, neuroendocrine tumors, acromegaly, Cushing's disease, and metabolic disorders. Selective SSTR5 agonists and next-generation somatostatin analogs continue to be actively investigated to improve therapeutic efficacy and receptor selectivity. The SSTR5 Stable Cell Line provides a valuable tool for studying somatostatin receptor biology and accelerating the discovery of novel endocrine therapeutics.
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