About Human Very Low-Density Lipoprotein Receptor (VLDLR) Stable Cell Line

Very Low-Density Lipoprotein Receptor (VLDLR) is a member of the low-density lipoprotein receptor (LDLR) family and plays important roles in lipid metabolism, neuronal development, cellular signaling, and viral entry. VLDLR is widely expressed in tissues such as the brain, heart, skeletal muscle, adipose tissue, and reproductive organs, where it mediates the uptake of triglyceride-rich lipoproteins and participates in diverse physiological processes. In addition to its function in lipid transport, VLDLR serves as a receptor for Reelin, a key extracellular matrix protein involved in neuronal migration, cortical layering, and brain development.

VLDLR has gained increasing attention in both neuroscience and infectious disease research. In the central nervous system, VLDLR-mediated Reelin signaling regulates neuronal positioning, synaptic plasticity, and cognitive function. Mutations or dysregulation of VLDLR have been associated with developmental neurological disorders and cerebellar hypoplasia. More recently, VLDLR has been identified as a host factor involved in the cellular entry of several viruses, including certain alphaviruses, making it an important target for studies of virus-host interactions and antiviral therapeutic development.

eEnzyme's Human VLDLR Stable Cell Line provides a reliable and reproducible cellular platform for investigating VLDLR-mediated biological processes and receptor-ligand interactions. The cell line enables functional evaluation of receptor binding, signaling pathways, viral entry mechanisms, antibody characterization, and therapeutic candidate screening. Researchers can utilize this stable cell line to investigate lipid receptor biology, Reelin signaling, host-pathogen interactions, and drug discovery programs targeting VLDLR-associated pathways.

Applications of the VLDLR Stable Cell Line

• VLDLR receptor-ligand interaction studies
• Reelin signaling and neurobiology research
• Lipoprotein uptake and lipid metabolism investigations
• Viral entry and host-pathogen interaction studies
• Antibody screening and characterization
• Drug discovery and therapeutic development
• Cell signaling and receptor biology research
• High-throughput screening applications

Biological Significance of VLDLR

VLDLR is a multifunctional receptor that contributes to both lipid metabolism and cellular signaling. As a member of the LDL receptor family, VLDLR mediates uptake of triglyceride-rich lipoproteins and helps regulate lipid homeostasis in peripheral tissues. In the nervous system, VLDLR functions as a major receptor for Reelin and participates in signaling pathways that control neuronal migration, brain development, and synaptic organization. Defects in VLDLR signaling have been linked to developmental neurological abnormalities and impaired cognitive function. In addition, recent studies have identified VLDLR as a host receptor involved in viral attachment and entry, expanding its significance in infectious disease research. Because of its diverse biological functions and emerging therapeutic relevance, VLDLR remains an important target for investigations in neuroscience, metabolism, virology, and translational medicine.