The Ebola virus nucleoprotein (NP) is the major structural protein of the viral nucleocapsid and is essential for viral RNA encapsidation, genome replication, and transcription. NP binds the viral negative-sense RNA genome to form the ribonucleoprotein (RNP) complex together with VP35, VP30, and the viral RNA-dependent RNA polymerase (L), protecting the viral genome and facilitating efficient virus replication. Because NP is one of the most abundant and highly conserved Ebola virus proteins, it is widely used as a target for viral detection, immunological studies, and diagnostic assay development.

eEnzyme's Anti-Nucleoprotein (NP) Zaire Ebolavirus Rabbit Polyclonal Antibody is generated against recombinant Ebola virus NP and recognizes multiple epitopes across the nucleoprotein. The antibody is suitable for applications including ELISA, Western blotting, immunofluorescence, immunohistochemistry, antigen characterization, viral protein detection, and basic filovirus research.

Selected Citation:
Rabb, M. Ebola virus nucleocapsid-like particles demonstrate consistent assembly, but a wide range of helical condensation. (2017).