About HIV-1 HXBc2 gp120 Recombinant Protein

Human Immunodeficiency Virus Type 1 (HIV-1) is an enveloped retrovirus belonging to the genus Lentivirus in the family Retroviridae. The gp120 envelope glycoprotein is the surface subunit of the HIV-1 Env complex and plays an essential role in viral attachment and entry by binding the CD4 receptor and the chemokine co-receptors CCR5 or CXCR4 on susceptible host cells. As the principal surface antigen of HIV-1, gp120 is the primary target of neutralizing antibodies and has been extensively studied for HIV vaccine development and antiviral research. The HXBc2 isolate is a well-characterized laboratory-adapted subtype B strain that has been widely used in structural, immunological, and receptor-binding studies.

eEnzyme's HIV-1 HXBc2 gp120 Recombinant Protein is produced for research use and is suitable for antibody screening, receptor-binding studies, ELISA development, Western blotting, epitope mapping, structural characterization, and HIV vaccine research. This recombinant protein provides a valuable reagent for investigating HIV-1 entry mechanisms, host-virus interactions, and immune responses.

Applications

Biological Significance of HIV-1 HXBc2 gp120

HIV-1 gp120 is the key viral attachment protein that initiates infection by recognizing the CD4 receptor and chemokine co-receptors on target cells. The HXBc2 gp120 protein has served as a reference antigen in numerous structural and immunological studies, providing important insights into receptor recognition, immune evasion, and broadly neutralizing antibody epitopes. Because gp120 remains a major target for HIV vaccine design and entry inhibitor development, the HIV-1 HXBc2 gp120 Recombinant Protein is a valuable research tool for studies of HIV biology, antibody responses, and therapeutic development.