Human Luteinizing Hormone/Choriogodadotropin Receptor (LHCGR) ACTOne Stable Cell Line
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Catalog Number:
CL-01-LHCGR
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In Stock
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Price: Please inquire order@eEnzyme.com
Detailed Description
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CL-01-LHCGR
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Name
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Human Luteinizing Hormone/Choriogodadotropin Receptor (LHCGR) ACTOneTM Stable Cell Line
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Description
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This cell line is a HEK-293-CNG cell line that expresses a recombinant human LHCGR. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization.
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Application
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cAMP dependent human LHCGR cell-based assay;
Cell-based high-throughput screening of human LHCGR agonists/antagonists.
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Size
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1x 106 cells
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Detection
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FlexStation or Microplate reader
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For Downloading
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==>> DATA SHEET ==>> MSDS
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Synonym: Luteinizing Hormone/Choriogonadotropin Receptor, LGR, LGR2, LHR, ULG5, Lutropin-Choriogonadotropic Hormone Receptor, Hypergonadotropic Hypogonadism, Luteinizing Hormone Receptor, LH/CG-R, LHRHR, LSH-R, HHG, Lutropin/Choriogonadotropin Receptor, LH/CGR
About Human Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR/LHR) Stable Cell Line
Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR), also known as the Luteinizing Hormone Receptor (LHR) or LH/CG Receptor, is a Class A G protein-coupled receptor (GPCR) that is activated by both luteinizing hormone (LH) and human chorionic gonadotropin (hCG). LHCGR primarily couples to Gs proteins, stimulating adenylate cyclase activity and increasing intracellular cAMP levels, while also activating additional signaling pathways involved in steroidogenesis and reproductive function. The receptor is predominantly expressed in ovarian granulosa and theca cells, luteal cells, and testicular Leydig cells, where it plays essential roles in ovulation, corpus luteum formation, testosterone production, and fertility.
LHCGR is a critical regulator of human reproduction and endocrine physiology. Dysregulation of LHCGR signaling has been associated with infertility, hypogonadism, Leydig cell disorders, polycystic ovary syndrome (PCOS), and reproductive cancers, making the receptor an important therapeutic target for reproductive medicine and assisted reproductive technologies.
eEnzyme's Human LHCGR Stable Cell Line provides a reliable platform for investigating LHCGR-mediated signaling and evaluating LH, hCG, agonists, antagonists, and novel receptor modulators using cAMP and other GPCR functional assays. The cell line is well suited for receptor characterization, compound profiling, potency determination, and high-throughput drug screening.
Applications
• LHCGR (LHR) receptor pharmacology studies
• LH and hCG signaling research
• Agonist and antagonist screening
• Reproductive biology and fertility research
• Steroidogenesis studies
• Assisted reproductive technology (ART) research
• cAMP and GPCR functional assays
• High-throughput screening (HTS)
Biological Significance of LHCGR
LHCGR is the primary receptor mediating the biological effects of LH and hCG in both males and females. Activation of the receptor stimulates Gs-mediated cAMP signaling, promoting steroid hormone synthesis, follicular maturation, ovulation, corpus luteum maintenance, and testosterone production. During pregnancy, hCG activation of LHCGR supports corpus luteum function and progesterone production, which are essential for early gestation. Because of its central role in reproductive endocrinology, LHCGR has become an important target for infertility treatment, reproductive medicine, contraceptive development, and endocrine research. The LHCGR Stable Cell Line provides a valuable tool for studying gonadotropin receptor biology and accelerating the discovery of next-generation therapeutics targeting reproductive and endocrine disorders.
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