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SARS-CoV-1, MERS-CoV and SARS-CoV-2 are Coronaviruses. SARS-CoV-2 is a novel human pathogen that spread into a pandemic COVID19 since late 2019. Other human pathogenic coronaviruses known include HCoV-NL63, HCoV-229E, HCoV-OC43 and HKU1, but SARS-CoV-1, MERS-CoV and particularly SARS-CoV-2 have been the most worrisome. They usually attack the respiratory, intestinal, and maybe nerve systems of their hosts.

Coronaviruses contain a +ssRNA genome (rangeing 26.4~31.7kb, the largest RNA viruses). Of particular interest is the Spike (S) protein that mediates cell entry and gives the virus its typical “corona” around the viral envelope in which it is embedded when visualized under EM. The ORFs 1a and 1b encode the replicase polyprotein (pp1ab). The replicase polyprotein self cleaves to form 16 nonstructural proteins (nsp1–nsp16). The later ORFs encode the four major structural proteins: spike, envelope, membrane, and nucleocapsid. Interspersed between these ORFs are the ORFs for the accessory proteins. The number of accessory proteins and their function is unique depending on the specific coronavirus.

SARS-CoV-2 is a 125nm-diameter, spherical-shaped β-coronavirus. It has four structural proteins: the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope.

           
                                                                                                                                                                                

Subtype/Strain

Product Name

Description

Catalogue #

SARS-CoV-2  Full-length Spike Protein, HEK293 C-terminal His-tag SCV2-S-050P
(COVID19) S1 Protein, HEK293 C-terminal His-tag SCV2-S1-150P
Spike S1(D614G) Protein, HEK293 C-terminal His-tag SCV2-S1-614G
Spike S1(UK Variant B.1.1.7) Protein, HEK293 C-terminal His-tag SCV2-S1-UKp
Spike S1(South Africa Variant B.1.351) Protein, HEK293 C-terminal His-tag SCV2-S1-SAp
Spike RBD (aa 319-541) protein, HEK293 C-terminal His-tag SCV2-RBD-050P
  Spike RBD (aa 309-528) protein, HEK293 C-terminal hFc-tag SCV2-RBD-060P
Spike RBD protein (Omicron variant B.1.1.529), HEK293 His-tag SCV2-RBD-OmicronP
Spike RBD protein (UK variant B.1.1.7), HEK293 His-tag SCV2-RBD-UK50P
Spike RBD protein (South Africa variant B.1.351), HEK293 His-tag SCV2-RBD-SA50P
Spike RBD protein (Brazil variant P1), HEK293 His-tag SCV2-RBD-BR50P
Spike RBD protein (Delta variant B.1.617.2), HEK293 His-tag SCV2-RBD-IN2P
Spike RBD protein (Delta plus variant B.1.617.2.1 or AY.1), HEK293 His-tag SCV2-RBD-Delta2P
Spike RBD protein (E484K mutation), HEK293 His-tag SCV2-RBD-E484Kp
Spike RBD protein (L452R mutation), HEK293 His-tag SCV2-RBD-L452Rp
Spike RBD protein (S477N mutation), HEK293 His-tag SCV2-RBD-S477Np
Membrane protein (M), E. coli N-terminal His-tag SCV2-M-050P

 

Envelope protein (E), E. coli

N-terminal His-SUMO tag

SCV2-E-050P
Nucleocapsid protein, E. coli C-terminal His-tag SCV2-NP-050P
Anti-Spike protein neutralization antibody Human IgG SCV2-SA-11m
Anti-Spike protein (Omicron) monoclonal antibody - reacts with spikes of many major variants Human IgG SCV2-S-400m
Anti-SARS-CoV-2, Biosimilar of Therapeutic Antibody - reacts with spikes of many major variants Human IgG SCV2-BeMab
Anti-Spike protein polyclonal antibody - reacts with spikes of many major variants Rabbit IgG SCV2-SA-200
Anti-Spike protein polyclonal antibody - reacts with spikes of all major variants (Alpha, Beta, Delta, Omicron) Rabbit IgG SCV2-S-300
Anti-Spike protein (SARS-CoV-2/South Africa Variant) polyclonal antibody Rabbit Serum SCV2-SA-255
Anti-Spike protein polyclonal antibody Rabbit IgG SCV2-S-100
Anti-Spike RBD mouse monoclonal antibody mouse IgG1 SCV2-RBD-01m
Anti-Spike RBD human monoclonal antibody Human IgG1 SCV2-RBD-100m
Anti-Spike RBD neutralizing antibody Human IgG SCV2-RBD-200m
Anti-Spike RBD human neutralization antibody Human IgG1 SCV2-RBD-h12
Anti-Spike RBD human monoclonal antibody Human IgG1 SCV2-RBD-h26
Anti-Spike S1 mouse monoclonal antibody mouse IgG1 SCV2-S1-21m
Anti-Spike S1 human monoclonal antibody Human IgG1 SCV2-S1-h22
Anti-Spike S1 human monoclonal antibody Human IgM SCV2-S1-h25
Anti-SARS-CoV-2 S2 mouse monoclonal antibody Mouse IgG1 SCV2-S2-001
Anti-NP polyclonal antibody Rabbit IgG SCV2-NP-100
Anti-M (aa 159-186) polyclonal antibody Rabbit IgG NCV-M-005
Anti-Membrane Protein Antibody Rabbit IgG SCV2-M-100
Anti-Envelope Protein (SARS-CoV-2) Antibody Rabbit IgG SCV2-E-100
SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron B.2 sub-variant spike protein) Replication-deficient pseudovirus SCV2-PsV-OmiBA2
SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron B.2.75 sub-variant spike protein) Replication-deficient pseudovirus SCV2-PsV-BA2.75
SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron B.2.12.1 sub-variant spike protein)  Replication-deficient pseudovirus SCV2-PsV-BA2.12.1
SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron BQ.1 sub-variant spike protein) Replication-deficient pseudovirus SCV2-PsV-BQ1
SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron BQ.1.1 sub-variant spike protein) Replication-deficient pseudovirus SCV2-PsV-BQ1.1
SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron XBB sub-variant spike protein) Replication-deficient pseudovirus SCV2-PsV-XBB

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron BA.4 sub-variant spike protein) 

Replication-deficient pseudovirus

SCV2-PsV-BA4

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron BA.4.7 sub-variant spike protein)

Replication-deficient pseudovirus

SCV2-PsV-BA4.7

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron BA.5 sub-variant spike protein)

Replication-deficient pseudovirus

SCV2-PsV-BA5

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron BA.5.9 sub-variant spike protein)

Replication-deficient pseudovirus

SCV2-PsV-BA5.9

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron (B.1.1.529) variant spike protein) 

Replication-deficient pseudovirus

SCV2-PsV-Omicron

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron (BF.1) sub-variant spike protein)

Replication-deficient pseudovirus

SCV2-PsV-BF7

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron (BJ.1) sub-variant spike protein) 

Replication-deficient pseudovirus

SCV2-PsV-BJ1

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Omicron XBB.1.5 sub-variant spike protein) 

Replication-deficient pseudovirus

SCV2-PsV-XBB1.5

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the CM.2 subtype spike protein) 

Replication-deficient pseudovirus

SCV2-PsV-CM2

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Deltacron variant spike protein) 

Replication-deficient pseudovirus

SCV2-PsV-Deltacron

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the original spike protein), 10 mL 

Replication-deficient pseudovirus

SCV2-PsV-001

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the original spike protein), 5 mL 

Replication-deficient pseudovirus

SCV2-PsV-0011

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Alpha (UK B.1.1.7) variant spike)

Replication-deficient pseudovirus

SCV2-PsV-UK

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Gamma (Brazil P.1) variant spike)

Replication-deficient pseudovirus

SCV2-PsV-BR

 

SARS-CoV-2 Pseudoviral Particles [pseudotyped with the Beta (South Africa B.1.351) variant spike]

Replication-deficient pseudovirus

SCV2-PsV-SA

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Indian B.1.617 variant spike)

Replication-deficient pseudovirus

SCV2-PsV-IN

 

SARS-CoV-2 Pseudoviral Particles [pseudotyped with the Delta (Indian B.1.617.2) variant spike]

Replication-deficient pseudovirus

SCV2-PsV-Delta

 

SARS-CoV-2 Pseudoviral Particles [pseudotyped with the Lambda (Peru C.37) variant spike]

Replication-deficient pseudovirus

SCV2-PsV-Lambda

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the 614G variant spike)

Replication-deficient pseudovirus

SCV2-PsV-614G

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the A222V-D614G variant spike)

Replication-deficient pseudovirus

SCV2-PsV-222V

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Y453F-D614G variant spike)

Replication-deficient pseudovirus

SCV2-PsV-453F

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the N501Y-D614G variant spike)

Replication-deficient pseudovirus

SCV2-PsV-501Y

 

MLV Pseudoviral Particles, negative control 

Replication-deficient pseudovirus

PsV-001

 

Recombinant human Angiotensin-Converting Enzyme 2 (hACE2) protein

Full length, no tag

hACE2-050P

 

Anti-ACE2 mouse monoclonal antibody

Mouse IgG

ACE2-MAb11

 

Human Angiotensin-Converting Enzyme 2 (hACE2) Stable Cell Line. with GFP reporter

HEK293-ACE2 stable cell line

CL-hACE2-001

 

Human Angiotensin-Converting Enzyme 2 (hACE2) Stable Cell Line

HEK293-ACE2 stable cell line

CL-hACE2-002

 

Human Neuropilin-1 (NRP-1) Stable Cell Line

HEK293-NRP1-ACE2 stable cell line

CL-NRP1-001

 

Human Angiotensin II Receptor Type 1 (AGTR-1, AT1R) Stable Cell Line

HEK293-AT1R stable cell line

CL-AT1R-001

Human Transmembrane Protease, Serine 2 (TMPRSS-2) Stable Cell Line

HEK293-TMPRSS2-ACE2 stable cell line

CL-TMPRSS2-001

SARS-CoV

Spike protein (amino acid 1-1190), HEK293 cells

C-terminal his-tag

SS-001-005P

 

Spike RBD Domain of SARS-CoV, HEK293 cells

C-terminal his-tag

SCV-RBD-035P

 

Anti-Spike (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-001-0100

 

Anti-E (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-005-0100

 

Anti-NP (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-006-0100

 

Anti-Spike (aa 19-48)(SARS-CoV)

Rabbit IgG

SCV-S-001

 

Anti-Spike (aa 278-312)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-005

 

Anti-Spike (aa 368-419)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-006

 

Anti-Spike (aa 450-479)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-007

 

Anti-E (aa 48-76)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-E-001

 

Anti-M (aa 4-26)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-M-001

 

Anti-M (aa 132-161)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-M-002

 

Anti-M (aa 158-185) polyclonal antibody

Rabbit IgG

NCV-M-005

 

SARS Pseudoviral Particles (pseudotyped with the SARS spike)

Replication-deficient pseudovirus

SCV1-PsV-003

 

 cADP-Ribose Assay Kit (Fluorescence)

Assay Kit

CA-CADP10

MERS-CoV

MERS-CoV Spike S1 Protein (aa 18-725)

C-terminal his-tag

MERS-S1-005P

 

MERS-CoV Spike RBD Protein (aa 367-588)

C-terminal his-tag

MERS-RBD-005P

 

Anti-spike (MERS-CoV) antibody, rabbit IgG

Rabbit IgG

MERS-S1-015

 

Anti-spike (MERS-CoV) antibody, rabbit anti-serum

Rabbit serum

MERS-S1-020

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-001

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-005

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-006

 

MERS Pseudoviral Particles (pseudotyped with MERS spike)

Replication-deficient pseudovirus

MERS-PsV-001

 

 

 

 

Other Coronavirus

Anti-Spike (HCoV-HKU1) Rabbit Polyclonal Antibody

Rabbit IgG

HKU1-S-100

 

 

 

 


Selected Citations of our SARS-CoV-2 products applied in COVID research:

1) A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters. Emerging Microbes & Infections, May 2021

2) Immunogenicity and Neutralizing Activity Comparison of SARS-CoV-2 Spike Full-Length and Subunit Domain Proteins in Young Adult and Old-Aged Mice. Vaccines, Feb. 2021

3) Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection. Clinical Infectious Diseases, Sept. 2020

4) Comparative analyses of SARS-CoV-2 binding (IgG, IgM, IgA) and neutralizing antibodies from human serum samples. Journal of Immunological Methods, Feb. 2021.

5) Characterisation of SARS-CoV-2 lentiviral pseudotypes and correlation between pseudotype-based neutralisation assays and live virus-based micro neutralisation assays. Viruses 12, 1011 (2020).


More COVID19/SARS-CoV-2 information and resources:


Check out the ten facts about the COVID-19 virus

* Here is a good tool for exploring accruing mutations in hCoV-19 (SARS-CoV-2) geographically and over time, with an emphasis on the Spike protein, using data from GISAID:  COVID-19 Viral Genome Analysis Pipeline

COVID-19 Reserch Registry   top-ranked, COVID-19 research articles curated by experts, a scientific resource on SARS-CoV-2

* NEJM Coronavirus (COVID19) and Vaccine Resources  original articles, correspondence, perspectives, review articles, opinions

* A detailed animated visual consensus molecular working model of different stages of the SARS-CoV-2 life cycle by researchers at University of Utah

Variant Genome Viewer  variants mutation comparison

ABOUT the SARS-CoV-2 Alpha (UK/Kent) variant (B.1.1.7)  
ABOUT the SARS-CoV-2 Beta (South Africa) variant (B.1.351)
ABOUT the SARS-CoV-2 Gamma (Brazil) variant (P.1)
ABOUT the SARS-CoV-2 Indian variant (B.1.617)
ABOUT the SARS-CoV-2 Delta (Indian) variant (B.1.617.2)
ABOUT the SARS-CoV-2 Omicron variant (B.1.1.529)
ABOUT the Deltacron variant (B.1.617.2+AY.*)

* CDC: SARS-CoV-2 Variants of Interest (VOI) and Variants of Concern (VOC)

WHO: SARS-CoV-2 Variants of Interest (VOI) and Variants of Concern (VOC)






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Updated on 1/3/2023