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SARS-CoV-1, MERS-CoV and SARS-CoV-2
are Coronaviruses. SARS-CoV-2 is a novel human pathogen that spread into a pandemic COVID19 since the start of the outbreak in late 2019. Other human pathogenic coronaviruses known include HCoV-NL63, HCoV-229E, HCoV-OC43 and HKU1, but SARS-CoV-1, MERS-CoV and particularly SARS-CoV-2 have been the most worrisome. They usually attack the respiratory, intestinal, and maybe nerve systems of their hosts.

Coronaviruses contain a +ssRNA genome (rangeing 26.4~31.7kb, the largest RNA viruses). The genome is polycistronic with a large pre-polypetide translated that is processed by proteolytic cleavage to most of the viral structural and proteolytic processing proteins. Of particular interest is the Spike (S) protein that mediates cell entry and gives the virus its typical “corona” around the viral envelope in which it is embedded when visualized under EM.

The genome organization for a coronavirus is visualized below:

The ORFs 1a and 1b encode the replicase polyprotein (pp1ab). The replicase polyprotein self cleaves to form 16 nonstructural proteins (nsp1–nsp16). The later ORFs encode the four major structural proteins: spike, envelope, membrane, and nucleocapsid. Interspersed between these ORFs are the ORFs for the accessory proteins. The number of accessory proteins and their function is unique depending on the specific coronavirus.

SARS-CoV-2 is a 125nm-diameter, spherical-shaped β-coronavirus. It has four structural proteins: the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope.

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Subtype/Strain

Product Name

Description

Catalogue #

SARS-CoV-2 (COVID19)

Full-length Spike Protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal His-tag

SCV2-S-050P

 

S1 Protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal His-tag

SCV2-S1-150P

 

Spike S1(D614G) Protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal His-tag

SCV2-S1-614G

 

Spike S1(UK Variant B.1.1.7) Protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal His-tag

SCV2-S1-UKp

 

Spike S1(South Africa Variant B.1.351) Protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal His-tag

SCV2-S1-SAp

 

Spike RBD (aa 319-541) protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal His-tag

SCV2-RBD-050P

 

Spike RBD (aa 309-528) protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal hFc-tag

SCV2-RBD-060P

 

Membrane protein (M) (SARS-CoV-2/COVID-19), E. coli

N-terminal His-tag

SCV2-M-050P

 

Envelope protein (E) (SARS-CoV-2/COVID-19), E. coli

N-terminal His-SUMO tag

SCV2-E-050P

 

Nucleocapsid protein (SARS-CoV-2/COVID-19), E. coli

C-terminal His-tag

SCV2-NP-050P

 

Anti-Spike protein (SARS-CoV-2) polyclonal antibody

Rabbit IgG

SCV2-S-100

 

Anti-Spike RBD (SARS-CoV-2/COVID-19) human monoclonal antibody

Human IgG1

SCV2-RBD-100m

 

Anti-Spike RBD (SARS-CoV-2/COVID-19) neutralizing antibody

Human IgG

SCV2-RBD-200m

 

Anti-Spike RBD (SARS-CoV-2/COVID-19) human neutralizing antibody

Human IgG1

SCV2-RBD-h12

 

Anti-Spike RBD (SARS-CoV-2/COVID-19) human monoclonal antibody

Human IgG1

SCV2-RBD-h26

 

Anti-Spike S1 (SARS-CoV-2) mouse monoclonal antibody

mouse IgG1

SCV2-S1-21m

 

Anti-Spike S1 (SARS-CoV-2/COVID-19) human monoclonal antibody

Human IgG1

SCV2-S1-h22

 

Anti-Spike S1 (SARS-CoV-2/COVID-19) human monoclonal antibody

Human IgM

SCV2-S1-h25

 

Anti-NP (SARS-CoV-2/COVID-19) polyclonal antibody

Rabbit IgG

SCV2-NP-100

 

Anti-M (aa 159-186)(SARS-CoV-2/2019-nCoV) polyclonal antibody

Rabbit IgG

NCV-M-005

 

Anti-M (aa 188-215)(SARS-CoV-2/2019-nCoV) polyclonal antibody

Rabbit IgG

SCV2-M-100

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the original spike protein) 

Replication-deficient pseudovirus

SCV2-PsV-001

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the UK B.1.1.7 variant spike)

Replication-deficient pseudovirus

SCV2-PsV-UK

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Brazil P1 variant spike)

Replication-deficient pseudovirus

SCV2-PsV-BR

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the South Africa B.1.351 variant spike)

Replication-deficient pseudovirus

SCV2-PsV-SA

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the 614G variant spike)

Replication-deficient pseudovirus

SCV2-PsV-614G

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the A222V-D614G variant spike)

Replication-deficient pseudovirus

SCV2-PsV-222V

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the Y453F-D614G variant spike)

Replication-deficient pseudovirus

SCV2-PsV-453F

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the N501Y-D614G variant spike)

Replication-deficient pseudovirus

SCV2-PsV-501Y

 

MLV Pseudoviral Particles, negative control 

Replication-deficient pseudovirus

PsV-001

 

Recombinant human Angiotensin-Converting Enzyme 2 (hACE2) protein

Full length, no tag

hACE2-050P

 

Human Angiotensin-Converting Enzyme 2 (hACE2) Stable Cell Line. with GFP reporter

HEK293-ACE2 stable cell line

CL-hACE2-001

 

Human Angiotensin-Converting Enzyme 2 (hACE2) Stable Cell Line

HEK293-ACE2 stable cell line

CL-hACE2-002

 

Human Neuropilin-1 (NRP-1) Stable Cell Line

HEK293-NRP1 stable cell line

CL-NRP1-001

 

Human Angiotensin II Receptor Type 1 (AGTR-1, AT1R) Stable Cell Line

HEK293-AT1R stable cell line

CL-AT1R-001

SARS-CoV

Spike protein (amino acid 1-1190), HEK293 cells

C-terminal his-tag

SS-001-005P

 

Spike RBD Domain of SARS-CoV, HEK293 cells

C-terminal his-tag

SCV-RBD-035P

 

Anti-Spike (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-001-0100

 

Anti-E (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-005-0100

 

Anti-NP (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-006-0100

 

Anti-Spike (aa 19-48)(SARS-CoV)

Rabbit IgG

SCV-S-001

 

Anti-Spike (aa 278-312)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-005

 

Anti-Spike (aa 368-419)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-006

 

Anti-Spike (aa 450-479)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-007

 

Anti-E (aa 48-76)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-E-001

 

Anti-M (aa 4-26)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-M-001

 

Anti-M (aa 132-161)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-M-002

 

Anti-M (aa 158-185) polyclonal antibody

Rabbit IgG

NCV-M-005

 

 

 

 

MERS-CoV

MERS-CoV Spike S1 Protein (aa 18-725)

C-terminal his-tag

MERS-S1-005P

 

MERS-CoV Spike RBD Protein (aa 367-588)

C-terminal his-tag

MERS-RBD-005P

 

Anti-spike (MERS-CoV) antibody, rabbit IgG

Rabbit IgG

MERS-S1-015

 

Anti-spike (MERS-CoV) antibody, rabbit anti-serum

Rabbit serum

MERS-S1-020

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-001

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-005

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-006

 

 

 

 

Other Coronavirus

Anti-Spike (HCoV-HKU1) Rabbit Polyclonal Antibody

Rabbit IgG

HKU1-S-100

 

 

 

 

 

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More COVID19/SARS-CoV-2 information and resources:

Check out the ten new facts about the COVID-19 virus
  
Here is a very useful tool for exploring accruing mutations in hCoV-19 (SARS-CoV-2) geographically and over time, with an emphasis on the Spike protein, using data from GISAID: COVID-19 Viral Genome Analysis Pipeline (link: https://cov.lanl.gov/content/index)

COVID-19 Reserch Registry 
 top-ranked, COVID-19 research articles curated by experts, a scientific resource on SARS-CoV-2

* NEJM Coronavirus (COVID19) and Vaccine Resources original articles, correspondence, perspectives, review articles, opinions

* Here is the link to Genome Wide Association Studies of COVID-19 -- for public download: https://grasp.nhlbi.nih.gov/Covid19GWASResults.aspx

ABOUT the SARS-CoV-2 UK mutant 

* Amino Acid Changes in Spike in Some Popular Variants (including the UK variant B.1.1.7, the South Africa variant B.1.351, Mink Cluster 5 variant)


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Updated on 1/31/2021