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Home > Coronavirus Research Tools
Coronavirus Research Tools
SARS-CoV-1, MERS-CoV and SARS-CoV-2 belong the subfamily of Coronaviruses. SARS-CoV-2 is a novel human pathogen that spread into a pandemic COVID19 that has caused large number of deaths worldwide and immense economic damage since the start of the outbreak in late 2019.
Other human pathogenic coronaviruses known include HCoV-NL63, HCoV-229E, HCoV-OC43 and HKU1, but SARS-CoV-1, MERS-CoV and particularly SARS-CoV-2 have been the most worrisome. They usually attack the respiratory, intestinal, and maybe nerve systems of their hosts.
Coronaviruses contain a positive-sense, single-stranded RNA genome. The genome size ranges from 26.4 to 31.7 kilobases and is among the largest RNA viruses. The genome is polycistronic with a large pre-polypetide translated that is processed by proteolytic cleavage to most of the viral structural and proteolytic processing proteins. Of particular interest is the Spike (S) protein that mediates cell entry and gives the virus its typical “corona” around the viral envelope in which it is embedded when visualized under EM.
The genome organization for a coronavirus is visualized below:
 
The ORFs 1a and 1b encode the replicase polyprotein (pp1ab). The replicase polyprotein self cleaves to form 16 nonstructural proteins (nsp1–nsp16). The later ORFs encode the four major structural proteins: spike, envelope, membrane, and nucleocapsid. Interspersed between these ORFs are the ORFs for the accessory proteins. The number of accessory proteins and their function is unique depending on the specific coronavirus.
SARS-CoV-2 is a 125nm-diameter, spherical-shaped β-coronavirus. It has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope.
Our related products (recombinant proteins, antibodies, pseudoviral particles, et al.):
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Subtype/Strain
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Product Name
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Description
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Catalogue #
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SARS-CoV-2 (COVID19)
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Full-length Spike Protein (SARS-CoV-2/COVID-19), HEK293 cells
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C-terminal His-tag
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SCV2-S-050P
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S1 Protein (SARS-CoV-2/COVID-19), HEK293 cells
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C-terminal His-tag
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SCV2-S1-150P
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Spike S1(D614G) Protein (SARS-CoV-2/COVID-19), HEK293 cells
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C-terminal His-tag
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SCV2-S1-614G
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Spike RBD (aa 319-541) protein (SARS-CoV-2/COVID-19), HEK293 cells
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C-terminal His-tag
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SCV2-RBD-050P
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Spike RBD (aa 309-528) protein (SARS-CoV-2/COVID-19), HEK293 cells
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C-terminal hFc-tag
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SCV2-RBD-060P
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Membrane protein (M) (SARS-CoV-2/COVID-19), E. coli
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N-terminal His-tag
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SCV2-M-050P
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Envelope protein (E) (SARS-CoV-2/COVID-19), E. coli
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N-terminal His-SUMO tag
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SCV2-E-050P
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Nucleocapsid protein (SARS-CoV-2/COVID-19), E. coli
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C-terminal His-tag
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SCV2-NP-050P
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Anti-Spike protein (SARS-CoV-2) polyclonal antibody
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Rabbit IgG
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SCV2-S-100
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Anti-Spike RBD (SARS-CoV-2/COVID-19) human monoclonal antibody
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Human IgG1
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SCV2-RBD-100m
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Anti-Spike RBD (SARS-CoV-2/COVID-19) neutralizing antibody
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Human IgG
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SCV2-RBD-200m
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Anti-Spike RBD (SARS-CoV-2/COVID-19) human neutralizing antibody
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Human IgG1
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SCV2-RBD-h12
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Anti-Spike RBD (SARS-CoV-2/COVID-19) human monoclonal antibody
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Human IgG1
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SCV2-RBD-h26
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Anti-Spike S1 (SARS-CoV-2) mouse monoclonal antibody
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mouse IgG1
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SCV2-S1-21m
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Anti-Spike S1 (SARS-CoV-2/COVID-19) human monoclonal antibody
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Human IgG1
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SCV2-S1-h22
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Anti-Spike S1 (SARS-CoV-2/COVID-19) human monoclonal antibody
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Human IgM
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SCV2-S1-h25
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Anti-NP (SARS-CoV-2/COVID-19) polyclonal antibody
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Rabbit IgG
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SCV2-NP-100
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Anti-M (aa 159-186)(SARS-CoV-2/2019-nCoV) polyclonal antibody
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Rabbit IgG
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NCV-M-005
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Anti-M (aa 188-215)(SARS-CoV-2/2019-nCoV) polyclonal antibody
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Rabbit IgG
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SCV2-M-100
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SARS-CoV-2 Pseudoviral Particles (pseudotyped with the original spike protein)
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Replication-deficient pseudovirus
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SCV2-PsV-001
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SARS-CoV-2 Pseudoviral Particles (pseudotyped with the 614G variant spike)
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Replication-deficient pseudovirus
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SCV2-PsV-614G
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SARS-CoV-2 Pseudoviral Particles (pseudotyped with the A222V variant spike)
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Replication-deficient pseudovirus
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SCV2-PsV-222V
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SARS-CoV-2 Pseudoviral Particles (pseudotyped with the UK B117 variant spike)
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Replication-deficient pseudovirus
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Available soon
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SARS-CoV-2 Pseudoviral Particles (pseudotyped with the N501Y variant spike)
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Replication-deficient pseudovirus
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Available soon
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SARS-CoV-2 Pseudoviral Particles (pseudotyped with the South Africa variant spike)
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Replication-deficient pseudovirus
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Available soon
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MLV Pseudoviral Particles, negative control
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Replication-deficient pseudorus
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PsV-001
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Recombinant human Angiotensin-Converting Enzyme 2 (hACE2) protein
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Full length, no tag
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hACE2-050P
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Human Angiotensin-Converting Enzyme 2 (hACE2) Stable Cell Line
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HEK293-ACE2 stable cell line
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CL-hACE2-001
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Human Neuropilin-1 (NRP-1) Stable Cell Line
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HEK293-NRP1 stable cell line
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CL-NRP1-001
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Human Angiotensin II Receptor Type 1 (AGTR-1, AT1R) Stable Cell Line
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HEK293-AT1R stable cell line
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CL-AT1R-001
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SARS-CoV
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Spike protein (amino acid 1-1190), HEK293 cells
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C-terminal his-tag
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SS-001-005P
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Spike RBD Domain of SARS-CoV, HEK293 cells
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C-terminal his-tag
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SCV-RBD-035P
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Anti-Spike (SARS-CoV) polyclonal antibody
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Rabbit IgG
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SS-001-0100
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Anti-E (SARS-CoV) polyclonal antibody
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Rabbit IgG
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SS-005-0100
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Anti-NP (SARS-CoV) polyclonal antibody
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Rabbit IgG
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SS-006-0100
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Anti-Spike (aa 19-48)(SARS-CoV)
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Rabbit IgG
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SCV-S-001
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Anti-Spike (aa 278-312)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-S-005
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Anti-Spike (aa 368-419)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-S-006
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Anti-Spike (aa 450-479)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-S-007
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Anti-E (aa 48-76)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-E-001
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Anti-M (aa 4-26)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-M-001
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Anti-M (aa 132-161)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-M-002
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Anti-M (aa 158-185) polyclonal antibody
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Rabbit IgG
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NCV-M-005
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MERS-CoV
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MERS-CoV Spike S1 Protein (aa 18-725)
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C-terminal his-tag
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MERS-S1-005P
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MERS-CoV Spike RBD Protein (aa 367-588)
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C-terminal his-tag
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MERS-RBD-005P
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Anti-spike (MERS-CoV) antibody, rabbit IgG
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Rabbit IgG
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MERS-S1-015
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Anti-spike (MERS-CoV) antibody, rabbit anti-serum
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Rabbit serum
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MERS-S1-020
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Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody
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Mouse IgG1
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MERS-S1-001
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Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody
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Mouse IgG1
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MERS-S1-005
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Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody
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Mouse IgG1
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MERS-S1-006
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Other Coronavirus
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Anti-Spike (HCoV-HKU1) Rabbit Polyclonal Antibody
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Rabbit IgG
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HKU1-S-100
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More COVID19/SARS-CoV-2 information and resources:
* Check out the ten new facts about the COVID-19 virus
* Here is a very useful tool for exploring accruing mutations in hCoV-19 (SARS-CoV-2) geographically and over time, with an emphasis on the Spike protein, using data from GISAID: COVID-19 Viral Genome Analysis Pipeline (link: https://cov.lanl.gov/content/index)
* COVID-19 Reserch Registry top-ranked, COVID-19 research articles curated by experts, a scientific resource on SARS-CoV-2
* Here is the link to Genome Wide Association Studies of COVID-19 -- for public download: https://grasp.nhlbi.nih.gov/Covid19GWASResults.aspx
* ABOUT the SARS-CoV-2 UK mutant NEW! Updated on 12/20/2020
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