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Home > Coronavirus Research Tools
Coronavirus Research Tools
SARS-CoV-1, MERS-CoV and SARS-CoV-2 belong the subfamily of Coronaviruses. Coronaviruses are relatively less studied as human pathogens. SARS-CoV-2 is a novel human pathogen that spread into a pandemic COVID19 causing hundreds of thousands of deaths worldwide and immense economic damage over the course of less than a year from the start of the outbreak in late 2019
Other human pathogenic coronaviruses now known include HCoV-NL63, HCoV-229E, HCoV-OC43 and HKU1, but SARS-CoV-1, MERS-CoV and particularly SARS-CoV-2 have been the most worrisome. They usually attack the respiratory and intestinal systems of their hosts.
Coronaviruses contain a positive-sense, single-stranded RNA genome. The genome size for coronaviruses ranges from 26.4 to 31.7 kilobases and is one of the largest among RNA viruses. The genome is polycistronic with a large pre-polypetide translated that is processed by proteolytic cleavage to most of the viral structural and proteolytic processing proteins. Of particular interest is the Spike (S) protein that mediates cell entry and gives the virus its typical “corona” around the viral envelope in which it is embedded when visualized under EM.
The genome organization for a coronavirus is visualized below:
 
The open reading frames 1a and 1b encode the replicase polyprotein (pp1ab). The replicase polyprotein self cleaves to form 16 nonstructural proteins (nsp1–nsp16). The later reading frames encode the four major structural proteins: spike, envelope, membrane, and nucleocapsid. Interspersed between these reading frames are the reading frames for the accessory proteins. The number of accessory proteins and their function is unique depending on the specific coronavirus.
SARS-CoV-2 is a 125nm-diameter, spherical-shaped β-coronavirus. Like other coronaviruses, SARS-CoV-2 has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope.
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Subtype/Strain
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Product Name
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Description
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Catalogue #
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SARS-CoV-2 (COVID-19)
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S1 Protein (SARS-CoV-2/COVID-19), HEK293 cells
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C-terminal His-tag
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SCV2-S1-150P
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Spike RBD (aa 319-541) protein (SARS-CoV-2/COVID-19), HEK293 cells
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C-terminal His-tag
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SCV2-RBD-050P
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Spike RBD (aa 309-528) protein (SARS-CoV-2/COVID-19), HEK293 cells
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C-terminal hFc-tag
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SCV2-RBD-060P
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Membrane protein (M) (SARS-CoV-2/COVID-19), E. coli
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N-terminal His-tag
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SCV2-M-050P
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Envelope protein (E) (SARS-CoV-2/COVID-19), E. coli
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N-terminal His-SUMO tag
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SCV2-E-050P
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Nucleocapsid protein (SARS-CoV-2/COVID-19), E. coli
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C-terminal His-tag
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SCV2-NP-050P
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Anti-Spike protein (SARS-CoV-2) polyclonal antibody
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Rabbit IgG
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SCV2-S-100
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Anti-Spike RBD (SARS-CoV-2/COVID-19) human monoclonal antibody
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Human IgG1
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SCV2-RBD-100m
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Anti-Spike RBD (SARS-CoV-2/COVID-19) human neutralizing antibody
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Human IgG1
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SCV2-RBD-h12
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Anti-Spike RBD (SARS-CoV-2/COVID-19) human monoclonal antibody
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Human IgG1
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SCV2-RBD-h26
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Anti-Spike RBD domain (SARS-CoV-2) mouse monoclonal antibody
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Mouse IgG1
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SCV2-RBD-01m
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Anti-Spike S1 (SARS-CoV-2) mouse monoclonal antibody
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mouse IgG1
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SCV2-S1-21m
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Anti-Spike S1 (SARS-CoV-2/COVID-19) human monoclonal antibody
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Human IgG1
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SCV2-S1-h22
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Anti-Spike S1 (SARS-CoV-2/COVID-19) human monoclonal antibody
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Human IgM
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SCV2-S1-h25
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Anti-NP (SARS-CoV-2/COVID-19) polyclonal antibody
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Rabbit IgG
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SCV2-NP-100
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Anti-NP (SARS-CoV-2/COVID-19) mouse monoclonal antibody
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Mouse IgG2a
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SCV2-NP-02m
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Anti-M (aa 159-186)(SARS-CoV-2/2019-nCoV) polyclonal antibody
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Rabbit IgG
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NCV-M-005
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Anti-M (aa 188-215)(SARS-CoV-2/2019-nCoV) polyclonal antibody
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Rabbit IgG
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SCV2-M-100
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SARS-CoV-2 Pseudoviral Particles (pseudotyped with the original spike protein) *please inquire info@eEnzyme.com*
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Replication-deficient particles
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SCV2-PsV-001
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SARS-CoV-2 Pseudoviral Particles (pseudotyped with the 614G variant spike protein) *please inquire info@eEnzyme.com*
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Replication-deficient particles
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SCV2-PsV-614G
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Recombinant human Angiotensin-Converting Enzyme 2 (hACE2) protein
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Full length, no tag
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hACE2-050P
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Human Angiotensin-Converting Enzyme 2 (hACE2) Stable Cell Line
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HEK293-ACE2 stable cell line
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CL-hACE2-001
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SARS-CoV
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Spike protein (amino acid 1-1190), HEK293 cells
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C-terminal his-tag
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SS-001-005P
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Spike RBD Domain of SARS-CoV, HEK293 cells
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C-terminal his-tag
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SCV-RBD-035P
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Anti-Spike (SARS-CoV) polyclonal antibody
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Rabbit IgG
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SS-001-0100
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Anti-E (SARS-CoV) polyclonal antibody
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Rabbit IgG
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SS-005-0100
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Anti-NP (SARS-CoV) polyclonal antibody
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Rabbit IgG
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SS-006-0100
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Anti-Spike (aa 19-48)(SARS-CoV)
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Rabbit IgG
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SCV-S-001
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Anti-Spike (aa 278-312)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-S-005
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Anti-Spike (aa 368-419)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-S-006
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Anti-Spike (aa 450-479)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-S-007
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Anti-E (aa 48-76)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-E-001
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Anti-M (aa 4-26)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-M-001
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Anti-M (aa 132-161)(SARS-CoV) polyclonal antibody
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Rabbit IgG
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SCV-M-002
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Anti-M (aa 158-185) polyclonal antibody
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Rabbit IgG
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NCV-M-005
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MERS-CoV
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MERS-CoV Spike S1 Protein (aa 18-725)
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C-terminal his-tag
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MERS-S1-005P
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MERS-CoV Spike RBD Protein (aa 367-588)
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C-terminal his-tag
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MERS-RBD-005P
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Anti-spike (MERS-CoV) antibody, rabbit IgG
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Rabbit IgG
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MERS-S1-015
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Anti-spike (MERS-CoV) antibody, rabbit anti-serum
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Rabbit serum
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MERS-S1-020
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Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody
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Mouse IgG1
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MERS-S1-001
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Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody
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Mouse IgG1
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MERS-S1-005
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Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody
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Mouse IgG1
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MERS-S1-006
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Other Coronavirus
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Anti-Spike (HCoV-HKU1) Rabbit Polyclonal Antibody
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Rabbit IgG
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HKU1-S-100
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