Search

Mailing Lists

Coronavirus Research Tools

SARS-CoV-1, MERS-CoV and SARS-CoV-2 belong the subfamily of Coronaviruses. Coronaviruses are relatively less studied as human pathogens. SARS-CoV-2 is a novel human pathogen that spread into a pandemic COVID19 causing hundreds of thousands of deaths worldwide and immense economic damage over the course of less than a year from the start of the outbreak in late 2019

Other human pathogenic coronaviruses now known include HCoV-NL63, HCoV-229E, HCoV-OC43 and HKU1, but SARS-CoV-1, MERS-CoV and particularly SARS-CoV-2 have been the most worrisome. They usually attack the respiratory and intestinal systems of their hosts.

Coronaviruses contain a positive-sense, single-stranded RNA genome. The genome size for coronaviruses ranges from 26.4 to 31.7 kilobases and is one of the largest among RNA viruses. The genome is polycistronic with a large pre-polypetide translated that is processed by proteolytic cleavage to most of the viral structural and proteolytic processing proteins. Of particular interest is the Spike (S) protein that mediates cell entry and gives the virus its typical “corona” around the viral envelope in which it is embedded when visualized under EM.

The genome organization for a coronavirus is visualized below:

The open reading frames 1a and 1b encode the replicase polyprotein (pp1ab). The replicase polyprotein self cleaves to form 16 nonstructural proteins (nsp1–nsp16). The later reading frames encode the four major structural proteins: spike, envelope, membrane, and nucleocapsid. Interspersed between these reading frames are the reading frames for the accessory proteins. The number of accessory proteins and their function is unique depending on the specific coronavirus.

SARS-CoV-2 is a 125nm-diameter, spherical-shaped β-coronavirus. Like other coronaviruses, SARS-CoV-2 has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope.

Subtype/Strain

Product Name

Description

Catalogue #

SARS-CoV-2 (COVID-19)

S1 Protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal His-tag

SCV2-S1-150P

 

Spike RBD (aa 319-541) protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal His-tag

SCV2-RBD-050P

 

Spike RBD (aa 309-528) protein (SARS-CoV-2/COVID-19), HEK293 cells

C-terminal hFc-tag

SCV2-RBD-060P

 

Membrane protein (M) (SARS-CoV-2/COVID-19), E. coli

N-terminal His-tag

SCV2-M-050P

 

Envelope protein (E) (SARS-CoV-2/COVID-19), E. coli

N-terminal His-SUMO tag

SCV2-E-050P

 

Nucleocapsid protein (SARS-CoV-2/COVID-19), E. coli

C-terminal His-tag

SCV2-NP-050P

 

Anti-Spike protein (SARS-CoV-2) polyclonal antibody

Rabbit IgG

SCV2-S-100

 

Anti-Spike RBD (SARS-CoV-2/COVID-19) human monoclonal antibody

Human IgG1

SCV2-RBD-100m

 

Anti-Spike RBD (SARS-CoV-2/COVID-19) human neutralizing antibody

Human IgG1

SCV2-RBD-h12

 

Anti-Spike RBD (SARS-CoV-2/COVID-19) human monoclonal antibody

Human IgG1

SCV2-RBD-h26

 

Anti-Spike RBD domain (SARS-CoV-2) mouse monoclonal antibody

Mouse IgG1

SCV2-RBD-01m

 

Anti-Spike S1 (SARS-CoV-2) mouse monoclonal antibody

mouse IgG1

SCV2-S1-21m

 

Anti-Spike S1 (SARS-CoV-2/COVID-19) human monoclonal antibody

Human IgG1

SCV2-S1-h22

 

Anti-Spike S1 (SARS-CoV-2/COVID-19) human monoclonal antibody

Human IgM

SCV2-S1-h25

 

Anti-NP (SARS-CoV-2/COVID-19) polyclonal antibody

Rabbit IgG

SCV2-NP-100

 

Anti-NP (SARS-CoV-2/COVID-19) mouse monoclonal antibody

Mouse IgG2a

SCV2-NP-02m

 

Anti-M (aa 159-186)(SARS-CoV-2/2019-nCoV) polyclonal antibody

Rabbit IgG

NCV-M-005

 

Anti-M (aa 188-215)(SARS-CoV-2/2019-nCoV) polyclonal antibody

Rabbit IgG

SCV2-M-100

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the original spike protein) *please inquire info@eEnzyme.com*

Replication-deficient particles

SCV2-PsV-001

 

SARS-CoV-2 Pseudoviral Particles (pseudotyped with the 614G variant spike protein) *please inquire info@eEnzyme.com*

Replication-deficient particles

SCV2-PsV-614G

 

Recombinant human Angiotensin-Converting Enzyme 2 (hACE2) protein

Full length, no tag

hACE2-050P

 

Human Angiotensin-Converting Enzyme 2 (hACE2) Stable Cell Line

HEK293-ACE2 stable cell line

CL-hACE2-001

SARS-CoV

Spike protein (amino acid 1-1190), HEK293 cells

C-terminal his-tag

SS-001-005P

 

Spike RBD Domain of SARS-CoV, HEK293 cells

C-terminal his-tag

SCV-RBD-035P

 

Anti-Spike (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-001-0100

 

Anti-E (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-005-0100

 

Anti-NP (SARS-CoV) polyclonal antibody

Rabbit IgG

SS-006-0100

 

Anti-Spike (aa 19-48)(SARS-CoV)

Rabbit IgG

SCV-S-001

 

Anti-Spike (aa 278-312)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-005

 

Anti-Spike (aa 368-419)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-006

 

Anti-Spike (aa 450-479)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-S-007

 

Anti-E (aa 48-76)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-E-001

 

Anti-M (aa 4-26)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-M-001

 

Anti-M (aa 132-161)(SARS-CoV) polyclonal antibody

Rabbit IgG

SCV-M-002

 

Anti-M (aa 158-185) polyclonal antibody

Rabbit IgG

NCV-M-005

 

 

 

 

MERS-CoV

MERS-CoV Spike S1 Protein (aa 18-725)

C-terminal his-tag

MERS-S1-005P

 

MERS-CoV Spike RBD Protein (aa 367-588)

C-terminal his-tag

MERS-RBD-005P

 

Anti-spike (MERS-CoV) antibody, rabbit IgG

Rabbit IgG

MERS-S1-015

 

Anti-spike (MERS-CoV) antibody, rabbit anti-serum

Rabbit serum

MERS-S1-020

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-001

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-005

 

Anti-S1 (MERS-CoV/HCoV-EMC/2012) Monoclonal Antibody

Mouse IgG1

MERS-S1-006

 

 

 

 

Other Coronavirus

Anti-Spike (HCoV-HKU1) Rabbit Polyclonal Antibody

Rabbit IgG

HKU1-S-100

 

 

 

 

 

 

 

 

 


.