hCD317, Ectodomain of Human CD317 (Tetherin) Protein
|
Catalog Number:
IV-317-005P
|
Detailed Description
|
IV-317-005P
|
|
Name
|
hCD317(∆TMs), Ectodomain of Human CD317 (Tetherin) Protein
|
|
Description
|
6xHis tagged ectodomain of human CD317 (Tetherin) protein (aa 24-162)
|
|
Source
|
Recombinant protein expressed and purified from HEK293 cells
|
|
Application
|
Interference of Vpr/CD317 interaction, Western blot standard, etc.
|
|
Purity
|
> 95% (SDS-PAGE)
|
|
Size
|
50 µg
|
|
For Downloading
|
==>> DATA SHEET
|
About Human CD317 (BST2/Tetherin) Recombinant Protein
CD317, also known as BST2 (Bone Marrow Stromal Cell Antigen 2), Tetherin, or HM1.24, is a type II transmembrane glycoprotein expressed on immune cells and many epithelial cell types. CD317 is an interferon-inducible antiviral restriction factor that inhibits the release of numerous enveloped viruses, including HIV-1, Ebola virus, Lassa virus, and Marburg virus, by physically tethering newly formed virions to the cell surface and preventing their dissemination. In addition to its antiviral function, CD317 participates in innate immune signaling, B-cell biology, and has emerged as a potential therapeutic target in multiple myeloma and other malignancies.
eEnzyme's Human CD317 (BST2/Tetherin) Recombinant Protein is produced for research use and is suitable for antibody generation, receptor and ligand interaction studies, ELISA development, Western blotting, epitope mapping, antiviral research, and immunological studies. This recombinant protein provides a valuable reagent for investigating innate immunity, virus-host interactions, and the development of antiviral therapeutics and immunotherapies.
Applications
Applications
• Innate immunity research
• Antiviral mechanism studies
• HIV and enveloped virus research
• Antibody generation and characterization
• ELISA and Western blot assays
• Protein-protein interaction studies
• Epitope mapping
• Immunotherapy research
Biological Significance of CD317 (BST2/Tetherin)
CD317 is a unique host restriction factor that suppresses the release of enveloped viruses by tethering budding virions to the plasma membrane, thereby limiting viral spread. Many pathogenic viruses have evolved specific mechanisms to antagonize CD317, highlighting its critical role in host antiviral defense. Beyond its antiviral activity, CD317 regulates innate immune responses and is highly expressed in several hematological malignancies, making it an important target for studies of viral pathogenesis, immune regulation, and therapeutic antibody development.
|
|
|