5-Hydroxytryptamine (Serotonin) Receptor 6 (HTR6) ACTOne Stable Cell Line
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Catalog Number:
CL-01-HTR6
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In Stock
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Price: Please inquire order@eEnzyme.com
Detailed Description
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CL-01-HTR6
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Name
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5-Hydroxytryptamine (Serotonin) Receptor 6 (HTR6) ACTOneTM Stable Cell Line
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Description
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This cell line is a HEK-293-CNG cell line that expresses a recombinant human HTR6. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader.
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Application
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cAMP dependent human HTR6 cell-based assay;
Cell-based high-throughput screening of human HTR6 agonists/antagonists.
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Size
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1x 106 cells
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Detection
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FlexStation or Microplate reader
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For Downloading
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==>> DATA SHEET ==>> MSDS
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Synonym: 5-Hydroxytryptamine Receptor 6, 5-HT6, 5-HT6R, 5-Hydroxytryptamine (Serotonin) Receptor 6 G Protein-Coupled, Serotonin Receptor 6, 5-Hydroxytryptamine (Serotonin) Receptor 6, 5-HT-6
About Human 5-Hydroxytryptamine Receptor 6 (HTR6/5-HT6R) Stable Cell Line
5-Hydroxytryptamine Receptor 6 (HTR6), commonly known as the 5-HT6 receptor (5-HT6R), is a Class A G protein-coupled receptor (GPCR) that is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). HTR6 primarily couples to Gs proteins, stimulating adenylate cyclase activity and increasing intracellular cAMP levels. Unlike many other serotonin receptors, HTR6 is expressed almost exclusively in the central nervous system, with high levels in the striatum, cortex, hippocampus, nucleus accumbens, and other brain regions involved in cognition, learning, memory, and mood regulation.
HTR6 plays important roles in cognitive function, synaptic plasticity, neurotransmitter release, and neuronal signaling. The receptor has emerged as a promising therapeutic target for Alzheimer's disease, schizophrenia, depression, anxiety, and other neuropsychiatric disorders.
eEnzyme's Human HTR6 Stable Cell Line provides a reliable platform for investigating HTR6-mediated signaling and evaluating agonists, antagonists, inverse agonists, and novel receptor modulators using cAMP and other GPCR functional assays. The cell line is well suited for receptor characterization, compound profiling, potency determination, and high-throughput drug screening.
Applications
• HTR6 (5-HT6R) receptor pharmacology studies
• Serotonin signaling research
• Agonist and antagonist screening
• Alzheimer's disease drug discovery
• Schizophrenia and cognitive disorder studies
• CNS and neuropsychiatric research
• cAMP and GPCR functional assays
• High-throughput screening (HTS)
Biological Significance of HTR6
HTR6 is an important mediator of serotonin signaling within the central nervous system. Activation of the receptor stimulates cAMP production through Gs-mediated signaling, influencing neurotransmitter release, neuronal excitability, synaptic plasticity, learning, and memory. Because HTR6 is highly enriched in brain regions associated with cognition and behavior, selective modulation of this receptor has attracted considerable interest for the treatment of Alzheimer's disease, schizophrenia, depression, and other cognitive disorders. HTR6 also serves as a valuable target for studying GPCR signaling, CNS pharmacology, and serotonin receptor biology. The HTR6 Stable Cell Line provides a robust tool for accelerating the discovery and characterization of next-generation therapeutics targeting neurological and psychiatric diseases.
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