Fusion Glycoprotein of Human Metapneumovirus (HMPV)
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Catalog Number:
HMPV-F-50p
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Detailed Description
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HMPV-F-50p
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Name
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F/Fusion Glycoprotein of Human Metapneumovirus (HMPV)
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Description
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C-His tagged HMPV fusion glycoprotein (amino acid 1-489)(GenBank accession# PP086007). A trimerization domain has been introduced into the C-terminal of fusion glycoprotein to stabilize the formation of trimer F-protein.
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Source
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Glycosylated recombinant viral protein expressed and purified from HEK293 cells
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Application
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Western Blot standard, antigen, antibody ELISA, etc.
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Purity
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≥95% (by SDS-PAGE)
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Endotoxin
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<0.01 EU per 1 µg of the protein by LAL test
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Size
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50 µg
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For Downloading
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==>> DATA SHEET ==>> MSDS
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About Human Metapneumovirus (hMPV) Fusion Glycoprotein Recombinant Protein
Human Metapneumovirus (hMPV) is an enveloped, negative-sense single-stranded RNA virus belonging to the genus Metapneumovirus in the family Pneumoviridae. The Fusion (F) glycoprotein is the major viral surface protein responsible for mediating fusion between the viral envelope and the host cell membrane, enabling viral entry. Unlike the attachment (G) protein, the F protein is highly conserved among hMPV strains and is the primary target of neutralizing antibodies, making it a key antigen for vaccine development and antiviral research.
eEnzyme's Human Metapneumovirus Fusion Glycoprotein Recombinant Protein is produced for research use and is suitable for antibody screening, receptor-binding studies, ELISA development, Western blotting, epitope mapping, structural characterization, and vaccine research. This recombinant protein provides a valuable reagent for investigating hMPV entry mechanisms, host immune responses, and the development of vaccines and antiviral therapeutics.
Applications
• hMPV fusion protein research
• Neutralizing antibody screening
• ELISA and Western blot assays
• Epitope mapping
• Structural biology studies
• hMPV vaccine research
• Viral entry and membrane fusion studies
• Antiviral therapeutic development
Biological Significance of Human Metapneumovirus Fusion Glycoprotein
The hMPV F protein is essential for viral infection by mediating membrane fusion and viral entry into susceptible host cells. It undergoes a conformational transition from the prefusion to the postfusion state during infection, with the prefusion conformation containing the major neutralizing epitopes recognized by protective antibodies. Because of its critical role in viral entry and immunity, the F protein has become the principal antigen for studies of hMPV pathogenesis, vaccine development, therapeutic antibody discovery, and antiviral drug research. The Human Metapneumovirus Fusion Glycoprotein Recombinant Protein provides a valuable tool for basic and translational hMPV research.
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